British Air Force Typhoon FGR4s have conducted a mission with France's air force in a coordinated attack targeting an underground arms cache in Syrian territory used by the IS group, according to the UK's MoD.
The location, identified by surveillance, was believed to be containing munitions and bombs, the statement said, and was positioned in mountainous terrain just above the ancient city of Palmyra in the heart of Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a number of entry passages leading to the facility... preliminary assessments indicate the objective was successfully hit," the MoD said.
There was no evidence of any harm to civilians in the attack on Saturday evening and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as the so-called Islamic State - established extremist governance over parts of Syria and Iraq before its territorial defeat in 2019.
"This operation demonstrates the UK's leading role, and commitment to operate in unison with our partners, to eradicate any revival of IS and their harmful and extremist ideologies in the area," the British Defence Secretary John Healey stated.
UK warplanes have conducted patrols over Syrian airspace to "prevent any attempted resurgence" of IS subsequent to its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank all the members of British forces participating in this strike for their expertise and their bravery," he said. "They were part of numerous UK service members stationed over the festive period. This action, to take out terrorist threats who endanger our way of life, highlights how UK forces are always on standby, throughout the year, protecting the UK at home and influential overseas."
In December, the United States armed forces carried out what it described as a "major assault" targeting Islamic State objectives in the country, subsequent to an assault claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The UN estimates Daesh still maintains roughly 5-7 thousand fighters in Syria and Iraq.
